One of our most important activities is to facilitate agreements on short term (3-5 months) research collaborations. In such projects of mutual interest to the involved parties a member will typically provide a certain type of complex experimental data that they wish subjected to the latest type of sophisticated bioinformatics analysis – for example by integration with other data types and computer generated predictions.

If successful such initial projects may lead to more long term collaborations, important personal contacts and joint scientific publications. The projects are of very different nature - a testimony to the diversity of areas where bioinformatics can make a difference in biomedical R&D.

BioSys pilot projects (some titles are hyperlinked to project descriptions):

1. KU[KVL] – Danske Slagterier “Identification of non coding RNA genes in porcine EST sequenses” – 4 months
2. AU – Novo Nordisk “Automated identification of metabolites from NMR spectra” – 3 months
3. AU – Sejet Planteforædling “Identifikation af selekterede kromosomsegmenter” – 2 months
4. CBS – Chr. Hansen A/S ”Operon finding in Probiotic Bacterial Genomes” – 2 months
5. CBS – Topotarget “Elucidating the transcriptional basis for dexrazoxane-mediated alleviation of etopside-induced myleosupression by microarray analysis” - 8 months
6. CBS – Novo Nordisk “Development of a support system for automated analysis of NMR based metabonomics data” - 4 months
7. CBS – Carlsberg BioSector “Development of a web tool to determine protein-protein interactions” – 1 month
8. CBS – Lundbeck “Mapping af functional space of exploratory ligand library” – 5 months
9. KU[KVL] – AstraZeneca “Computer based predictions of miRNA involved in inflammation and inflammatory deseases” – 4 months
10. CBS - NsGene “Identification of potential growth factors in the human proteome” - 3 months
11. AU – Novozymes “Fungal gene prediction” - 10 months
12. AU - Chr Hansen A/S ”In silico prediction of a 3Dstructure of chymosin interaction with k-casein. Differentiation between two species, bovin and camel” – 3months
13. AU - Chr Hansen A/S “Estimation of binding energies for the chymosin – k-casein complexes” – 5 months
14. KU - Exiqon A/S, “MicroRNA discovery by pyrosequencing” - 5 months
15. CBS - TopoTarget A/S (start 1 Dec) “Mode of action of a cancer agent TOP216 studied by gene expression studies” 5 months
16. KU - Zgene A/S ”Computational modelling of the Drosophila melanogaster deoxynucleoside kinase (Dm-dNK)” – 1 month
17. KU LIFE - Exiqon A/S “Platform for optimal prediction of iRNA sequences for knock-down experiments”
18. KU NAT - Santaris Pharma A/S “miBase – Foundation for a computational infrastructure for microRNA Research in Denmark”